Midamor is a highly effective potassium-sparing diuretic. This drug is a derived pyrazinoisoquinoline.
The drug works on the distal part of the renal tubules.
The drug improves the intensity of the excretion of sodium and chlorine ions, as well as a noticeable reduction in the excretion of potassium ions from the human body.
In addition, the drug causes a less pronounced diuretic effect than thiazide diuretics.
When the drug is combined with potassium-deducing diuretics, it decreases the risk of development of diseases such as hypokalemia or hypomagnesemia.
The instructions for use
Midamor belongs to a group of potassium-sparing diuretics, it is a derivative of such a compound as pyrazine-carbonyl-guanidine.
It acts on renal tubules and their distal part. This drug is recommended in case of edematous syndrome in anamnesis and in case of high blood pressure.
This diuretic increases the excretion of sodium and chlorine, and at the same time reduces the excretion of potassium. After oral administration there is a complete absorption of the substance from the gastrointestinal tract.
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Bioavailability is equal to 50%, and can be significantly reduced when eating.
The binding of Midamor with plasma proteins is weak. Half-life takes about nine hours, unchanged components of the drug are excreted through the kidneys.
Midamor should only be used in combination with other types of diuretics. This is necessary in order to avoid excretion of potassium from the body in too large quantities, because it is excreted along with the urine. This drug inhibits the process of losing not only potassium but also magnesium.
Indications for use
Midamor is prescribed for:
Edema syndrome of different genesis (with chronic heart failure, nephrotic syndrome, liver cirrhosis), hypertension.
As a diuretic drug in case of hypertensive disease (stable elevated arterial pressure) and heart failure. It is used primarily in combination with other diuretics (hydrochlorothiazide, etc.). Amiloride enhances their diuretic effect and reduces the risk of hypokalemia (lower potassium levels in the blood).
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Method of application and doses
The drug is taken inside. In case of edematous syndrome the magnitude of the initial dose is determined by the severity of violations of water-electrolyte metabolism and is 1-4 tablets a day.
After reaching effect the supportive care is carried out at the dosage of 1-2 tablets after 1-3 days.
In case of hypertension the initial dose is 1/2-1 tablet each day; after the desired hypotensive results – 1/2 tablet daily or every other day.
Form of release.
The drug is released in the form of tablets, where the standard dosage can be either a 2.5 or 5 milligrams. It should be clear that a patient can feel the effect of the pills only after two hours after reception, where the effect is saved during the day.
Moreover, these tablets have the most powerful ability designed to hold potassium in the body.
In addition, this drug is absorbed by the kidneys and liver in equal performance. But the reception should not be performed if a patient has obvious problems with these bodies, as accumulation of the drug may begin to have a negative impact.
In addition, potassium is excreted from the body in a less extent during the reception, so there can be accumulated so much of it that it will be already clearly unnecessary.
Thus, when using medications it is very important to constantly monitor the indicators of blood composition.
In most cases, Midamor is combined with some other diuretic drugs that reduce potassium in the blood, including drug hydrochlorothiazide.
Midamor is prescribed with caution in case of impaired renal function, if this condition is sufficiently pronounced, you should stop taking the drug.
Midamor interaction with other med. drugs:
While the use of ACE inhibitors (captopril, enalapril), there is increased risk of hyperkalemia, because the ACE inhibitors decrease the level of aldosterone, which causes retention of potassium in the human body.
While the use of Midamor and “loop” diuretics, thiazide diuretics and other diuretics that cause hypokalemia, it decreases the excretion of potassium.
While the use of potassium supplements, other potassium-sparing diuretics, salt substitutes and food supplements containing potassium, it may develop severe, life-threatening hyperkalemia.
While the use of amoxicillin amiloride, there is perhaps a slight decrease in the absorption of amoxicillin from the gastrointestinal tract.
The experiment on healthy volunteers showed that Midamor had no significant effect on the concentration of digoxin in the blood plasma, but reduced its positive inotropic effect. Patients with impaired renal function may suffer from the increase of the concentration of digoxin in plasma.
Concurrent use of Midamor and candesartan, eprosartan, losartan, telmisartan, valsartan, increases the risk of hyperglycemia.
When Midamor is combined with hydrochlorothiazide and trimethoprim, it may develop hyponatremia, which is due to additive action of diuretics, and trimethoprim.
The combined use of Midamor and quinidine reduces the efficacy of quinidine.