In the second half of the last century, antibiotics from the drug group of cephalosporins began to be widely used in medicine. Medical scientists are constantly improving these antibacterial drugs, as previously pathogenic microorganisms quickly developed resistance to them. However, the first-generation cephalosporins are still not withdrawn from production. They still have not lost their relevance in the treatment of infectious and inflammatory diseases of bacterial origin, especially in the initial stages of therapy. As a rule, having a wide spectrum of antimicrobial action, cephalosporin antibiotics can make miracles. They are successfully used to treat people who are allergic to penicillin group drugs. And only when the doctor is convinced of their insufficient effectiveness, the medicines of the latest developments are connected. One of the frequently prescribed semi-synthetic cephalosporins of the first generation is Keflex, the instruction for its use notes its active bactericidal action against a number of pathogenic microflora.
The antibacterial effect of Keflex is that when entering the body of a sick person, the drug starts the process of suppressing the enzymatic activity of endopeptidases, carboxypeptidases, trans-peptidases, which take a direct part in the synthesis of the main component of the walls of bacterial cells – the biopolymer peptidoglycan. This mechanism of action breaks the strength and integrity of the bacterial cell wall, destroys it and causes the death of the microorganism. The antimicrobial activity of cephalexin extends to pneumococcal, streptococcal, staphylococcal, klebsiella, shigella, salmonella, proteus, haemophilus and escherichia coli. For the sake of justice, it should be noted that this medication is ineffective against enterococci, protozoa and mycobacteria that provoke the development of tuberculosis.
Keflex medicine is well absorbed from the digestive organs, reaching its highest concentration in the blood one hour after ingestion. Then, through the blood stream, the antibiotic enters the broncho-pulmonary and urinary system, the bile ducts and other internal organs that have been affected by infectious disease. The duration of antibacterial action depends on the state of immunity of a sick person, so it can take from 6 to 12 hours.
Indications for use
The bactericidal effect of Keflex is manifested in the treatment of infectious diseases such as pharyngitis, sinusitis, tonsillitis, bronchitis, pneumonia, cystitis, pyelonephritis, vulvovaginitis. No less effective is the use of cephalexin for furunculosis, pyoderma, osteomyelitis and other bacterial lesions, in which the pathogenic microflora is sensitive to this antibiotic.
Conditions for admission
The medication is taken orally (inside) 3-4 times a day. For the treatment of adults, tablets (capsules) are intended, and for children it is preferable to prepare a suspension from the powder (in view of possible difficulties with swallowing). The duration of the course of antibiotic therapy usually takes 2 weeks, but much depends on the diagnosis and severity of infection. For adults, the maximum daily dose should not exceed 2 grams of Cephalexin, and for children it is calculated on the basis of the principle of 25 to 50 milligrams of medication per kilogram of the child’s weight.
If there is a violation of kidney function, pseudomembranous colitis, individual immunity of cephalosporins, and children under the age of 3, this antibiotic is not prescribed. With great care and only with the permission of a doctor who evaluated the risk / benefit ratio, the drug is used in pregnancy and lactation.
Of negative manifestations on the part of the body after taking the antibiotic Keflex, the instructions for use highlight dizziness, excessive excitement, leg cramps, hallucinations, loss of appetite, epigastric pain, nausea, vomiting, diarrhea, thrombocytopenia, leukopenia. In the course of treatment, allergic reactions may occur: puffiness, itchy skin rashes, rarely anaphylactic shock. When taking Keflex, you must exclude the use of alcohol.
It is well known that many pathogens have long developed resistance to antibacterial agents of the penicillin series. It is then that cephalosporin antibiotics come to the rescue, including Cephalexin.