Hypersensitivity, hypotension, pregnancy, child age. It is used with caution in case of angina, coronary artery disease or decompensated diseases of the cardiovascular system, renal/hepatic failure, cerebrovascular disease, diabetes mellitus of the 1st type.
Method of application and dosage of Hytrin:
The drug is taken inside in case of arterial hypertension at an initial dose of 1 mg/day with a gradual increase to achieve the desired effect. Maintenance dose is from 1 to 10 mg 1 time / day; maximum daily dose is 20 mg.
Benign prostatic hyperplasia is treated by taking the initial dose of 1 mg before bedtime, and progressively increased to 2-10 mg/day. You may buy Hytrin on our website. Therapeutic effect is noted after 2 weeks since start of treatment. A lasting effect is achieved after a course of treatment – 4-6 weeks.
Pharmacological action of Hytrin:
Blocker of peripheral postsynaptic alpha1-adrenergic receptors causes dilation of arterioles and venules, reduces round and venous return to the heart, has hypotensive action.
Onset of action – 15 min. (single dose), the maximum effect is achieved within 2-3 h at a single dose and up to 6-8 weeks for multiple one. The duration of hypotensive effect is 24 h. The hypotensive effect is, as a rule, not accompanied by reflex tachycardia during the prolonged use. It promotes normalization of lipid metabolism: reduces total cholesterol, TG, LDL and VLDL in the blood, increases the amount of HDL. The systematic use causes regression of LV hypertrophy. Hytrin can be bought on our website. You will be able buy the drug in any quantities.
Blocking alpha1-adrenergic receptors of smooth muscles of the prostate and bladder neck, it helps to normalize urination of patients with benign prostatic hyperplasia.
Side effects of Hytrin:
Orthostatic hypotension (the phenomenon of “first dose” – often in combination therapy with diuretics or beta-blockers), collapse, palpitations, tachycardia, peripheral edema; asthenia, drowsiness, disturbances of clearness of vision; nasal congestion; nausea; decreased potency; the decrease in hematocrit, Hb, leukopenia, hypoproteinemia, hypoalbuminemia (due to hemodilution).
Symptoms: expressed lower AD, violations of coordination, fainting.
Treatment: lay the patient, lowering the head end of the bed. If necessary – you may use hypertensive drugs in intravenous fluids. Dialysis is ineffective.
Special instructions to Hytrin:
The treatment should be started with minimum effective doses (1 mg/day at bedtime), after which the patient must remain in bed for 6-8 hours in order to prevent the occurrence of the phenomenon of the first dose.
The risk of orthostatic hypotension (the phenomenon of “first dose”) is highest within 30-90 min after drug administration and increased in patients receiving both beta-blockers and diuretics, while reducing the volume of fluid in the body, hypocolius diet, and also when resuming treatment after a break (few days).
The therapy is resumed with the same dose in case of temporary discontinuation of treatment.
The concentration of prostate specific antigen (PSA) is not changed during the treatment.
Before starting therapy of benign prostatic hyperplasia it is necessary to exclude prostate cancer. The effectiveness of the therapy in this disease is evaluated after 4-6 weeks of treatment.
Patient must be informed about the increased risk of orthostatic hypotension in the use of ethanol, prolonged standing or exercise and in hot weather.
You should be careful when driving and occupation of other potentially hazardous activities, that require high concentration and psychomotor speed reactions within 12 h after the first dose, after an increase in dosage or interruption of therapy.
You can arrange delivery to any city buying Hytrin on our website.
Beta-blockers, diuretics, simpatolytics, ACE inhibitors enhance the hypotensive effect.
Adsorbents and antacids reduce the absorption.
The agonists weaken the effect.
NSAIDs (especially indomethacin) may decrease the hypotensive effect by inhibiting the synthesis of Pg and/or fluid retention and Na+.