Application and dose of the drug
Inside after eating; initially, 0.025 g 3 times a day, gradually increasing the dose (in the morning and at noon to 0,025 g, in the evening and before bedtime to 0,05 g). Sometimes the dose is increased to 0.3 g per day. After achieving the optimal therapeutic effect (3-4 weeks) pass to maintenance doses (0.04-0.1 g). Intravenous and intramuscular injection of 2 ml of a 1% solution 4-6 times a day (usually at the beginning of treatment). The course of treatment is 3-4 months.
Elavil hydrochloride and perphenazine (Triavil): film-coated tablets containing 10 mg amitriptyline hydrochloride and 2 mg perphenazine containing 25 mg amitriptyline hydrochloride and 2 mg perphenazine containing 10 mg amitriptyline hydrochloride and 4 mg perphenazine containing 25 mg amitriptyline hydrochloride and 4 Mg of perphenazine, containing 50 mg of amitriptyline hydrochloride and 4 mg of perphenazine.
Action of the medicine
Elavil is one of the strong antidepressant agents (timoleptic) with an undetectable mechanism of action. Does not inhibit monoamine oxidase. Elavil has quite pronounced tranquilizing and anxiolytic properties, which eliminates the phenomena of fear and depression, often observed with depression.
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Indications for use
Depressive form of manic-depressive psychosis, involutional melancholia, reactive depression, schizo-affective depression, neurotic depression reactions (especially form accompanied obsessive-ruminative trends).
To avoid the withdrawal syndrome, drug therapy should not be discontinued sharply, the dose of the drug should decrease gradually within one to two weeks.
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Carefully use in patients with diseases of the cardiovascular system, thyroid, convulsive seizures history, as well as patients who are contraindicated over-stimulation anticholinergic system (benign prostatic hypertrophy, urinary retention history, increasing IOP). The drug can be used when the coal form of glaucoma is closed only with a compensated form of the disease and with constant monitoring of IOP.
It is contraindicated in patients who take MAOIs, and within two weeks after receiving patients with recent myocardial infarction and in patients with hypersensitivity to amitriptyline in the anamnesis. Sometimes there is cross-sensitivity with other tricyclic antidepressants.
The drug can cause drowsiness, however it is contraindicated in individuals who deal with increased concentration, coordination of movements, increased risk (driving, work with heavy objects etc.). Daytime sleepiness can be reduced by reducing the dose of the drug, an earlier evening reception or substituting for a drug with less pronounced sedative effect.
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Glaucoma, prostatic hypertrophy, atony of the bladder. Do not administer simultaneously with monoamine oxidase inhibitors.
Possible side effects
Drowsiness, dizziness, heartburn, dry mouth, nausea, agitation, tremor, hypotension, headache, skin rash, tingling in the hands; tachycardia, visual impairment, urinary retention, constipation. May lead to the activation of latent schizophrenia.