In the fight against various pathogens of infections, doctors often use antibiotic drugs, natural origin and chemical antimicrobial drugs, created artificially. Of course, you should not overestimate the benefits of antibiotics, because these drugs destroy the microflora of the intestine, but with severe inflammation and infections, these drugs are often the only salvation. We’ll talk about one of them, namely about the antibacterial agent of the second generation of a group of fluoroquinolones called ciprofloxacin. Consider the mechanism of action, contraindications, as well as indications for the use of the drug Cipro.
Fluoroquinolones, which are the main active substances of Cipro., are artificially created chemicals developed in the eighties of the last century. The antibiotics of a wide spectrum of action created on their basis allow to struggle with infections of bones and soft tissues, a skin, respiratory ways, and also a gastrointestinal tract. In addition, indications for the use of this remedy are infections caused by campylobacteria, shigella, salmonella and other pathogens. Cipro. helps to defeat gonococcal infections, is used for sepsis, meningitis, and postoperative infectious complications. When taking an antibiotic inside, it quickly penetrates into the kidneys and destroys the dominant pathogenic agent, helping to cope with the complications of urinary tract infections. The drug is also assigned in the treatment of infections in patients with oncology.
Due to its antibacterial effect, ciprofloxacin is similar to other fluoroquinolones, but is more effective. For example, it is 8 times more effective than Norfloxacin.
Dosage and administration
This antibiotic is taken orally or is injected into the body parenterally, that is, bypassing the gastric tract. It should be noted that when taking the drug on an empty stomach, Cipro is well absorbed, reaching a maximum concentration in the blood after 1-2 hours (with the introduction of the drug intravenously – after 30 minutes). Approximately 40% of the drug is excreted in the urine within 24 hours.
Speaking about taking Cipro it is worth noting that with uncomplicated infections of the respiratory tract and the genitourinary system, the antibiotic is taken twice a day for 0,125-0,25 g. Infections with complications suggest taking 0.25-0.5 g of the drug twice a day. In the most severe cases, doctors prescribe 0.75 g of ciprofloxacin 2 times a day (if parenteral treatment is not performed). Duration of treatment with this drug is from 5 to 15 days.
In the treatment of particularly severe infections, as well as when it is not possible to take the drug in the form of tablets, Cipro is administered intravenously with short-term infusions, and it can be administered without dilution or diluted in a 5% solution of glucose. The solution concentrate in ampoules must be diluted before administration.
Uncomplicated cystitis (inflammation of the bladder), as well as gonorrhea should be treated with Cipro in a single dose of intravenous injection of 0.1 g or oral intake of 0.25 g. In a day, you must apply the drug 2 times. And, if the patient’s condition improves, the doctor advises to switch from intravenous administration to taking the drug in tablets.
Like any antibiotic, Cipro has a number of contraindications. So, the drug can’t be taken by patients with epilepsy, as well as persons with susceptibility to quinolones. The drug is contraindicated in nursing mothers, pregnant women, as well as teenagers under 15, because they have not yet completed the formation of the skeleton. For people with impaired renal function Cipro is prescribed in usual doses, but subsequently the doses are reduced taking into account the clearance of creatine. This drug can’t be used simultaneously with alkaline waters, as well as with antacid drugs, which reduce the acidity of the stomach.
Usually, ciprofloxacin is well tolerated. Most often, side effects manifest allergic reactions – rashes and skin itching. Occasionally, the preparation may cause swelling of the face, lack of appetite, vomiting and nausea, abdominal pain, diarrhea, as well as anxiety, sleep disturbance and changes in blood composition. In rare cases, taking the drug may disrupt the taste and perception of odor. It is important to know that in the treatment of ciprofloxacin and other fluoroquinolone-based drugs, it is advisable to avoid exposure to ultraviolet rays, that is, not to visit the solarium and reduce the time spent in the sun.